The Dose and Effects of Sodium Nitroprusside ( SNP ) on the Cardiovascular System During SNP - induced Hypotension under General Anesthesia with Enflurane .

Noh,  Kyu Jeong; Lee,  Byung Young; Moon,  Sun Hak; Im,  Sung Woon; Kim,  Kwang Woo; Suk,  Sei Il

doi:1989.22.5.681

Clinical Research Article

Korean Journal of Anesthesiology 1989;22(5):681-688.
DOI: https://doi.org/10.4097/kjae.1989.22.5.681

The Dose and Effects of Sodium Nitroprusside ( SNP ) on the Cardiovascular System During SNP - induced Hypotension under General Anesthesia with Enflurane .

Kyu Jeong Noh, Byung Young Lee, Sun Hak Moon, Sung Woon Im, Kwang Woo Kim, Sei Il Suk

¹Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
²Department of Orthopedic Surgery, College of Medicine, Seoul National University, Seoul, Korea.

Abstract

Sodium nitroprusside given by intravenous drip has been used to control hypertensive crises since 1929. Its evanescent action makes it suitable for controlled hypotension during general anesthesia with enflurane. The patients (n=10) were all undergoing Cotrel-Dubousset instrumentation for the operative treatment of scoliosis or spinal stenosis. Hemodynamic variables were obtained during administration of sodium nitroprusside. Mean arterial pressure was decreased to 50-60mmHg, while cardiac output, central venous pressure, systemic vascular resistance showed only minor changes. The average dosage of sodium nitroprusside (ug/kg/ min), plotted against age, showed a significant correlation (p<0.05, r= -0.63). The amonut of whole blood transfused during operation was 5.7+/-2.2 units (mean+/-SD) and postoperative hemoglobin and hematocrit (11.19+/-1.21g/dl, 33.49+/-3.79%, respectively, mean+/-SD) were singificantly lowered than preoperative hemoglobin and hematocrit (12.94+/-1.78g/dl, 37.22+/-4.88%, respectively, mean+/-SD) (hemoglobin: p<0.004, hematoorit: p<0.006).

Key Words: Controlled hypotension; Enflurane; Sodium Nitroprusside; Cotrel-Dubousset Instrumentation