Korean J Anesthesiol Search

CLOSE


Korean Journal of Anesthesiology 1989;22(5):681-688.
DOI: https://doi.org/10.4097/kjae.1989.22.5.681   
The Dose and Effects of Sodium Nitroprusside ( SNP ) on the Cardiovascular System During SNP - induced Hypotension under General Anesthesia with Enflurane .
Kyu Jeong Noh, Byung Young Lee, Sun Hak Moon, Sung Woon Im, Kwang Woo Kim, Sei Il Suk
1Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Orthopedic Surgery, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
Sodium nitroprusside given by intravenous drip has been used to control hypertensive crises since 1929. Its evanescent action makes it suitable for controlled hypotension during general anesthesia with enflurane. The patients (n=10) were all undergoing Cotrel-Dubousset instrumentation for the operative treatment of scoliosis or spinal stenosis. Hemodynamic variables were obtained during administration of sodium nitroprusside. Mean arterial pressure was decreased to 50-60mmHg, while cardiac output, central venous pressure, systemic vascular resistance showed only minor changes. The average dosage of sodium nitroprusside (ug/kg/ min), plotted against age, showed a significant correlation (p<0.05, r= -0.63). The amonut of whole blood transfused during operation was 5.7+/-2.2 units (mean+/-SD) and postoperative hemoglobin and hematocrit (11.19+/-1.21g/dl, 33.49+/-3.79%, respectively, mean+/-SD) were singificantly lowered than preoperative hemoglobin and hematocrit (12.94+/-1.78g/dl, 37.22+/-4.88%, respectively, mean+/-SD) (hemoglobin: p<0.004, hematoorit: p<0.006).
Key Words: Controlled hypotension; Enflurane; Sodium Nitroprusside; Cotrel-Dubousset Instrumentation


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
(서울특별시 마포구 마포대로 109 롯데캐슬 프레지던트 101동 3503호)
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                
Business Name: Korean Society of Anesthesiologists (대한마취통증의학회)
Business Registration: 106-82-07194
Representative: Young-Tae Jeon (전영태)

Copyright © 2025 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next