1. Dworkin RH, Corbin AE, Young JP Jr, Sharma U, LaMoreaux L, Bockbrader H, et al. Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology 2003; 60: 1274-1283. PMID:
12707429.
2. Rosenstock J, Tuchman M, LaMoreaux L, Sharma U. Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain 2004; 110: 628-638. PMID:
15288403.
3. Shneker BF, McAuley JW. Pregabalin: a new neuromodulator with broad therapeutic indications. Ann Pharmacother 2005; 39: 2029-2037. PMID:
16288079.
4. Gribkoff VK. The role of voltage-gated calcium channels in pain and nociception. Semin Cell Dev Biol 2006; 17: 555-564. PMID:
17141538.
5. Maneuf YP, Luo ZD, Lee K. Alpha-2-delta and the mechanism of action of gabapentin in the treatment of pain. Semin Cell Dev Biol 2006; 17: 565-570. PMID:
17067834.
6. Yaksh TL. Calcium channels as therapeutic targets in neuropathic pain. J Pain 2006; 7(1 Suppl 1): S13-S30. PMID:
16426997.
7. Sills GJ. The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol 2006; 6: 108-113. PMID:
16376147.
8. Schug SA, Saunders D, Kurowski I, Peach MJ. Neuraxial drug administration: a review of treatment options for anaesthesia and analgesia. CNS Drugs 2006; 20: 917-933. PMID:
17044729.
9. Kaneko M, Mestre C, Sánchez EH, Hammond DL. Intrathecally administered gabapentin inhibits formalin-evoked nociception and the expression of Fos-like immunoreactivity in the spinal cord of the rat. J Pharmacol Exp Ther 2000; 292: 743-751. PMID:
10640314.
10. Yoon MH, Choi JI, Jeong SW. Spinal gabapentin and antinociception: mechanism of action. J Korean Med Sci 2003; 18: 255-261. PMID:
12692425.
11. Chen SR, Pan HL. Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia. Brain Res 2005; 1042: 108-113. PMID:
15823259.
12. Cheng JK, Chen CC, Yang JR, Chiou LC. The antiallodynic action target of intrathecal gabapentin: Ca2+ channels, KATP channels or N-Methyl-D-Aspartic acid receptors? Anesth Analg 2006; 102: 182-187. PMID:
16368827.
13. Yaksh TL, Collins JG. Studies in animal should precede human use of spinally administered drugs. Anesthesiology 1989; 70: 4-6. PMID:
2912314.
14. Hassenbusch SJ, Portenoy RK, Cousins M, Buchser E, Deer TR, Du Pen SL, et al. Polyanalgesic consensus conferences 2003: an update on the management of pain by intraspinal drug delivery-report of an expert panel. J Pain Symptom Manage 2004; 27: 540-563. PMID:
15165652.
15. Hayashi N, Weinstein JN, Meller ST, Lee HM, Spratt KF, Gebhart GF. The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy. Spine (Phila Pa 1976) 1998; 23: 877-885. PMID:
9580954.
16. Kim YC, Lim YJ, Lee SC. Spreading pattern of epidurally administrated contrast media in rabbits. Acta Anaesthesiol Scand 1998; 42: 1092-1095. PMID:
9809094.
17. Kawakami M, Matsumoto T, Hashizume H, Kuribayashi K, Tamaki T. Epidural injection of cyclooxygenase-2 inhibitor attenuates pain-related behavior following application of nucleus pulposus to the nerve root in the rat. J Orthop Res 2002; 20: 376-381. PMID:
11918320.
18. Choi SS, Kim YC, Lim YJ, Lee CJ, Lee PB, Lee SC, et al. The neurological safety of epidural gabapentin in rats: a light microscopic examination. Anesth Analg 2005; 101: 1422-1426. PMID:
16244005.
19. Thalhammer JG, Vladimirova M, Bershadsky B, Strichartz GR. Neurologic evaluation of the rat during sciatic nerve block with lidocaine. Anesthesiology 1995; 82: 1013-1025. PMID:
7717536.
20. Bajrović F, Sketelj J. Extent of nociceptive dermatomes in adult rats is not primarily maintained by axonal competition. Exp Neurol 1998; 150: 115-121. PMID:
9514823.
21. Kawakami M, Weinstein JN, Spratt KF, Chatani K, Traub RJ, Meller ST, et al. Experimental lumbar radiculopathy. Immunohistochemical and quantitative demonstrations of pain induced by lumbar nerve root ligation of the rat. Spine (Phila Pa 1976) 1994; 19: 1780-1794. PMID:
7526474.
22. Madsen JB, Jensen FM, Faber T, Bille-Hansen V. Chronic catheterization of the epidural space in rabbits: a model for behavioral and histopathological studies: examination of meptzsinol neurotoxicity. Acta Anaesthesiol Scand 1993; 37: 307-313. PMID:
8517109.
23. Gurun MS, Leinbach R, Moore L, Lee CS, Owen MD, Eisenach JC. Studies on the safety of glucose and paraben-containing neostigmine for intrathecal administration. Anesth Analg 1997; 85: 317-323. PMID:
9249107.
24. Lim YJ, Sim WS, Kim YC, Lee SC, Choi YL. The neurotoxicity of epidural hyaluronic acid in rabbits: a light and electron microscopic examination. Anesth Analg 2003; 97: 1716-1720. PMID:
14633548.
25. Field MJ, McCleary S, Hughes J, Singh L. Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat. Pain 1999; 80: 391-398. PMID:
10204753.
26. Eutamene H, Coelho AM, Theodorou V, Toulouse M, Chovet M, Doherty A, et al. Antinociceptive effect of pregabalin in septic shock-induced rectal hypersensitivity in rats. J Pharmacol Exp Ther 2000; 295: 162-167. PMID:
10991974.
27. Chen SR, Xu Z, Pan HL. Stereospecific effect of pregabalin on ectopic afferent discharges and neuropathic pain induced by sciatic nerve ligation in rats. Anesthesiology 2001; 95: 1473-1479. PMID:
11748408.
28. Norton S. Is behavior or morphology a more sensitive indicator of central nervous system toxicity? Environ Health Perspect 1978; 26: 21-27. PMID:
363417.
29. Hodgson PS, Neal JM, Pollock JE, Liu SS. The neurotoxicity of drugs given intrathecally. Anesth Analg 1999; 88: 797-809. PMID:
10195528.