| Changes in hemodynamic parameters and regional myocardial perfusion measured by thermal diffusion probe from the infusion of norepinephrine during displacement of porcine beating heart. |
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Jong Wha Lee, Sou Ouk Bang, Han Ki Park, Jiwon An, Young Lan Kwak, Yong Woo Hong |
1Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea.
2Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
3Department of Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea.
4Department of Anesthesiology and Pain Medicine, Ajou University College of Medicine, Suwon, Korea. ywhong7292@gmail.com |
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| Abstract |
BACKGROUND
This study was done to evaluate the sole effect of norepinephrine on the regional myocardial perfusion during displacement of the porcine beating heart using thermal diffusion method.
METHODS
Thermal diffusion probe was inserted into the anterior myocardial wall during 20 procedures in 10 male pigs (30-35 kg). The measurements of regional myocardial perfusion and hemodynamic parameters were performed after complete instrumentation (baseline), after displacement of the beating heart anteriorly, and 5 and 15 minutes after norepinephrine infusion, titrated to restore baseline mean arterial pressure (MAP).
RESULTS
Norepinephrine infusion reversed the decrease in MAP and myocardial perfusion, caused by displacement of the beating heart (62 +/- 3% to 115 +/- 4% of baseline, P < 0.01; 41 +/- 5% to 125 +/- 4% of baseline, P < 0.05, respectively).
CONCLUSIONS
Restoration of MAP with norepinephrine infusion without any preload augmentation reversed deterioration in regional myocardial perfusion during displacement of the porcine beating heart. |
| Key Words:
myocardial perfusion; norepinephrine; off-pump coronary artery bypass graft |
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