| Fulminant Hepatitis after Operation - Two cases report. |
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Jae Seung Yun |
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Department of Anesthesiology, Won Kwang University College of Medicine, Iri, Korea. |
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| Abstract |
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Although halothane is one of the most widely used inhalational anesthetics, it may cause postanesthetic complications such as halothane hepatitis. Halothane hepatitis has been reported lintermittently since 1958 with variable incidence. Changes in hepatic functions by halothane hepatitis are usually mild and reversible but they may be fatal it the patient had already shock, sepsis, massive blood transfusion, previous hepatic disease, hypoxia or induction of microsomal enzyme system. Hepatitis due to blood transfusion has high incidence especially in Korea where 10~20% of all population has vital hepatitis. Most of transfusion hepatitis is also mild but it may progress to chronic condition and eventually death. We experienced 2 cases of fulminant hepatitis after operation. Several factors such as massive whole blood transfusion, upper abdominal trauma, inhalational anesthetic agent, induction of microsomal enzyme system and shock might be attributed to development of the fulminant hepatitis. |
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