| Effects of Long-term Intermittent Oxygen Administration on the Cognitive Function in Rats. |
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Seung Lyong Koo, Chul Hyun Kim, Hae Chul Ahn, Dong Won Kim, Kyoung Hun Kim, Chan Kim |
1Department of Anesthesiology and Pain Medicine, College of Medicine, Hanyang University, Seoul, Korea.
2Department of Physiology and Biophysics, School of Medicine, Eulji University, Daejeon, Korea. ckim@eulji.ac.kr |
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| Abstract |
BACKGROUND
Several studies have demonstrated that the transient administration of oxygen improves cognitive performance. However, the effect of long-term oxygen administration remains unknown. This study investigated the impact of long-term oxygen administration on cognitive enhancement. METHODS: Six week old Sprague-Dawley rats (n = 46) were randomly allocated to one of three groups: the control (Control; n = 15), 30 min/day oxygen administration (Oxy30min; n = 16) and 60 min/day oxygen administration groups (Oxy60min; n = 15). The rats in all three groups were administered air or oxygen for 10 weeks. The Morris water maze test was employed to assess the latency (L & Lt), dwelling time (DT) and the total fraction above the mean dwelling time (FmDT) for cognitive performance. RESULTS: Compared to the control group, the Oxy30min and Oxy60min groups showed no differences in their L and Lt. There was a dose-response trend due to oxygen administration. Compared to the control group, the Oxy60min group had a significantly improved DT (P< 0.05). The FmDT also significantly increased in both of the oxygen administration groups, which also showed a dose-response trend (P<0.05). CONCLUSIONS: The present results suggest that long-term (10 weeks) oxygen administration can dose-dependently enhance cognitive performance. |
| Key Words:
cognitive function; long-term oxygen administration; water maze |
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