| A Comparisons of Remifentanil versus Alfentanil-based Total Intravenous Anesthesia (TIVA) for Oocyte Retrieval. |
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Jeong Yeon Hong, Young Seok Jee, Jae Young Lee |
1Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Korea.
2Department of Anesthesiology and Pain Medicine, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea. jisaac@naver.com |
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| Abstract |
BACKGROUND
This prospective, randomized, double-blind study was carried out to compare the effect of remifentanil with that of alfentanil, as a part of total intravenous anesthesia (TIVA) on the hemodynamic profile, recovery characteristics, visual analogue scale (VAS) for postoperative pain, and serum cortisol changes in the patients undergoing oocyte retrieval.
METHODS
The patients were assigned to receive either propofol-remifentanil (n = 31) or propofol-alfentanil (n = 30). When the target propofol concentration (3.0microgram/ml) was reached, the study drugs were administered over a 60 s period with the loading dose (either remifentanil 1microgram/kg or alfentanil 10microgram/kg) and were maintained with a continuous infusion (either remifentanil 0.08microgram/kg/min or alfentanil 0.4microgram/kg/min). The propofol requirements, blood pressure, pulse rate, serum cortisol, VAS scores for pain, recovery profile and postoperative side effect were recorded in both the operating and recovery rooms.
RESULTS
There were significant differences in the VAS score for postoperative pain 30 minutes after oocyte retrieval between the two groups.
CONCLUSIONS
The propofol-remifentanil and propofol-alfe ntanil techniques are suitable for oocyte retrieval but the propofol-remifentanil technique requires additional analgesics for postoperative pain due to the rapid offset of remifentanil. |
| Key Words:
alfentanil; cortisol; postoperative pain; remifentanil; TIVA |
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