| Antinociceptive Effect of Intraperitoneally Administered 5,5-dimethyl-1-pyrroline N-oxide on Formalin Induced Nociception in Rats. |
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Woo suk Chung, Young gwon Go, Won hyung Lee |
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Department of Anesthesiology and Pain Medicine, Research Institute for Medicial Sciences,Chungnam National University College of Medicine, Daejeon, Korea. whlee@cnu.ac.kr |
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| Abstract |
BACKGROUND
Reactive oxygen species (ROS) is known to be involved in chronic and persistent pain.By using the ROS scavenger 5,5-dimethyl-1-pyrroline N-oxide (DMPO), we studied the effects of ROS on formalin-induced nociception in rats.
METHODS
5% formalin was injected in the left hind paw after intraperitoneal injection of saline or various doses of DMPO (10 mg/kg, 30 mg/kg, 100 mg/kg).Number of flinches was measured in a 5 minute interval for 1 hour.
RESULTS
Formalin injected into the left hind paw induced a biphasic nociceptive behaviour. Intraperitoneal injection of DMPO diminished nociceptive behaviors dose-dependently during phase 2 but not phase 1.
CONCLUSIONS
ROS might be involved in central sensitization and DMPO, a ROS scavenger, posses antinociceptive property in rats subjected to formalin induced hyperalgesia. |
| Key Words:
DMPO; formalin test; ROS |
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