| Effect of Preventive Nicardipine on Hemodynamics Induced by Pneumoperitoneum during Laparoscopic Cholecystectomy. |
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Jae Hoon Jeong, Dong Gun Lim |
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Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. dglim@knu.ac.kr |
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| Abstract |
BACKGROUND
Pneumoperitoneum for a laparoscopic cholecystectomy induces hemodynamic changes. The present study investigated the effect of preventive nicardipine on the hemodynamics induced by pneumoperitoneum during a laparoscopic cholecystectomy.
METHODS
Forty five patients, scheduled to undergo laparoscopic cholecystectomy, were selected, and divided into three groups; the control group (C; normal saline infusion), the nicardipine bolus injection group (NB; 20microgram/kg nicardipine infusion, 1 min before skin incision) and the nicardipine continuous infusion group (NI; 2microgram/kg/min continuous infusion, from the time of endotracheal intubation to pneumoperitoneum). The blood pressure, heart rate, cardiac output and systemic vascular resistance were measured; at preincision, and at 5, 10 and 15 min after insufflation and at 5 min after exsufflation.
RESULTS
Nicardipine injection attenuated increases in the blood pressure, systemic vascular resistance after pneumoperitoneum, and didn't attenuate decrease in the cardiac output.
CONCLUSIONS
A preventive nicardipine injection is effective in attenuating the hemodynamic change after pneumoperitoneum during a laparoscopic cholecystectomy, especially attenuated the systemic vascular resistance and blood pressure increase. |
| Key Words:
cholecystectomy; hemodynamics; laparoscopy; nicardipine; pneumoperitoneum |
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