Inhibition of Stuccinylcholine-induecd Increased Intraocular Pressure by d-Tubocurarine .

Kim,  Jong Hak; Lee,  Choon Hi

doi:1983.16.3.215

Clinical Research Article

Korean Journal of Anesthesiology 1983;16(3):215-220.
DOI: https://doi.org/10.4097/kjae.1983.16.3.215

Inhibition of Stuccinylcholine-induecd Increased Intraocular Pressure by d-Tubocurarine .

¹Department of Anesthesiology, Han Dok General Hospital, Seoul, Korea.
²Department of Anesthesiology, Ewha Woman University Hospital, Seoul, Korea.

Abstract

The effect of prior administration of d-tubocurarine on the increased intraocular pressure associated with the use of succinylcholine was studied in 30 randomely selected human subjects, who did not have cardiopulmonary or ocular disease preoperatively. Intraocular pressures were measured with Schiotz tonometer. The major findings of this study were as follows: 1) When succinylcholine was given alone, a rise from 15.5mmHg to 18.OmmHg (16.1%) was seen(p<0.05). 2) When d-tubocurarine, 3mg, was given three minutes prior to the administration of succylchin oline, 15 healthy human subjects had no significant increase in intraocular pressure(p>0.05). 3) Intrsocular pressure were significantly increased in both groups after endotracheal intubation, but the d-tubocurarine precurarization group had minimal pressure compured to the succinylcholine alonegroup(p<0.05). An intraocular pressure increase was inhibited in the d-tubocurarine precurarization group. This simple, convenient method prevents the increased intraocular pressure associated with the use of succinylcholine.