Population Pharmacokinetic and Pharmacodynamic Modeling in Beagle Dogs Sedated by Propofol Microemulsion.

Choi,  Byung Moon; Jung,  Sung Moon; Bae,  Kyun Seop; Noh,  Gyu Jeong

doi:2006.50.6.689

Original Article

Korean Journal of Anesthesiology 2006;50(6):689-697.
DOI: https://doi.org/10.4097/kjae.2006.50.6.689

Population Pharmacokinetic and Pharmacodynamic Modeling in Beagle Dogs Sedated by Propofol Microemulsion.

Byung Moon Choi, Sung Moon Jung, Kyun Seop Bae, Gyu Jeong Noh

¹Department of Anesthesiology and Pain Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea. nohgj@nate.com
²Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

Abstract

BACKGROUND
Aquafol(R) is a microemulsion formulation of propofol. This study was designed to investigate the population pharmacokinetic and pharmacodynamic modeling in beagle dogs sedated by Aquafol(R).
METHODS
Electroencephalogram was recorded and venous blood was sampled at preset times in 15 beagle dogs during 3 hours of infusion of Aquafol(R) and subsequently during 3 hours of recovery. Venous blood was sampled at 0, 2, 10, 30, 60, 120, 180, 190, 240 and 360 minutes after infusion. We evaluated the effect of propofol on electroencephalogram by calculating SEF(90). In the preliminary analysis, two compartment model best described all data from all subjects. The pharmacodynamics were best described using an effect compartment model and k(e0), a first-order elimination rate constant characterizing the effect-site equivalent to estimate the apparent effect-site concentrations. The relationship between propofol effect-site concentration and SEF90 was analyzed using an inhibitory sigmoid E(max) model. RESULTS: The final pharmacokinetic model was best described with the followings: V(1) = 18.5e(0.114*BWT), k(10) = 1.86 min(-1), k(12) = 0.6 min(-1), k(21) = 0.684 min(-1). The final pharmacodynamic model was best described with the followings: t(1/2)k(e0) = 0.62 min, C(e50) = 32.2 ng/ml, E(o) = 31.3 Hz, E(max) = 20.9 Hz, gamma = 1.28.
CONCLUSIONS
The propofol microemulsion shows different pharmacokinetics and pharmacodynamics compared with the propofol lipid emulsion.

Key Words: electroencephalogram; pharmacodynamic; pharmacokinetic; propofol; sedation