| The Effect of H1-Receptor Antagonist on Hemodynamic Change during Anesthesia. |
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Tae Soo Hahm, Chung Soo Kim, Myong Shin Koo, Byung Seop Shin, Hee Youn Hwang, Sang Min Lee, Hyun Sung Cho |
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Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. hscho@smc.samsung.co.kr |
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| Abstract |
baseline for safe use of a drug.
RESULTS
SVR and PVR failed to show statistically significant changes. Heart rates were increased only at 2 minute after administration of chlorpheniramine maleate.
Blood pressures were increased but returned to basal level within 4 minutes. Cardiac output showed statistically significant increase until 8 minutes. However, the changes of hemodynamic values were maintained within 20% of basal levels.
CONCLUSIONS
Chlorpheniramine maleate is observed to cause statistically significant hemodynamic change after intravenous administration during anesthesia. But the changes were within 20% of basal levels, and we can safely use chlorpheniramine maleate 8 mg IV in the view of hemodynamic changes. |
| Key Words:
antihistamine; chlorpheniramine maleate; hemodynamic change |
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