Effect of Preoperative Aspirin Use on Postoperative Bleeding and Thromboelastography in Off-Pump Coronary Artery Bypass Operations.

Kim,  Seung Ho; Kwak,  Young Lan; Oh,  Young Jun; Shinn,  Helen Ki; Kim,  Shin Hyung; Hong,  Yong Woo

doi:2005.48.3.235

Clinical Research Article

Korean Journal of Anesthesiology 2005;48(3):235-240.
DOI: https://doi.org/10.4097/kjae.2005.48.3.235

Effect of Preoperative Aspirin Use on Postoperative Bleeding and Thromboelastography in Off-Pump Coronary Artery Bypass Operations.

Seung Ho Kim, Young Lan Kwak, Young Jun Oh, Helen Ki Shinn, Shin Hyung Kim, Yong Woo Hong

¹Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. ylkwak@yumc.yonsei.ac.kr
²Department of Anesthesia and Pain Medicine Research Institute, Yonsei University College of Medicine, Seoul, Korea.
³Department of Anesthesiology and Pain Medicine, College of Medicine, Inha University, Incheon, Korea.

Abstract

BACKGROUND
Aspirin has been shown to effectively increase survival and reduce morbidity in patients with ischemic heart disease. Continued aspirin use during the preoperative period could increase the postoperative blood loss in patients who have on-pump coronary artery bypass grafting. This study aimed to determine the effect of continued aspirin use before off-pump CABG on intraoperative and postoperative bleeding and coagulation profile in thromboelastography.
METHODS
In 43 patients undergoing OPCAB, they were assigned aspirin user (n = 22), who received aspirin until the day of operation or nonaspirin user (n = 21), who discontinued aspirin before 7 days before the surgery. Intraoperative and postoperative bleeding and transfusion requirement were measured. TEG was performed and R, K, alpha angle, maximum amplitude and TEG index was measured at preinduction and at 24 hours after surgery.
RESULTS
There were no differences in patient characteristics between aspirin users and nonaspirin users. We found no significant difference between postoperative bleeding and blood product requirements for the two groups. Similarly, we found no significant difference in the coagulation profiles.
CONCLUSIONS
The use of aspirin continued preoperatively does not increase intraoperative and postoperative blood loss, and blood product requirement and influence on coagulation profile.

Key Words: off-pump coronary artery bypass graft surgery; aspirin; thromboelastography; coagulation