| The Effect of Pretreatment with Lidocaine for the Withdrawal Movement Associated with the Injection of Rocuronium in Children. |
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Kyong Sik Kim, Yun Jeong Chae, Sung Yong Park, Han Bum Cho, Jin Soo Kim |
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Department of Anesthesiology, School of Medicine, Ajou University, Suwon, Korea. lala06@freechal.com |
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| Abstract |
BACKGROUND
The purpose of this study was two fold; first, to determine the incidence and type of withdrawal movement associated with IV injection of rocuronium in pediatric patients; and second, to determine whether pretreatment with IV lidocaine affects the incidence of movement associated with rocuronium administration in pediatric patients.
METHODS
Forty-two pediatric patients were randomly assigned to two groups. After general anesthesia was induced with thiopental sodium 5 mg/kg and manual occlusion of venous inflow was performed, one group of patients received 0.1 ml/kg 1% lidocaine IV. A second group received 0.1 ml/kg of normal saline as a placebo control. Venous inflow occlusion was held for 5 seconds, and immediately followed by the injection of rocuronium 0.6 mg/kg IV. The patient's response to rocuronium injection was graded using a 5-point scale.
RESULTS
We observed that the incidence of movement was 100% in the placebo group and was significantly decreased to 28.8% in the group pretreated with lidocaine (P<0.001).
CONCLUSIONS
Withdrawal movement on injection of rocuronium in pediatric patients can be decreased or prevented by pretreatment with IV lidocaine. |
| Key Words:
Anesthetic; local; lidocaine; complication; movement; neuromuscular relaxants; rocuronium |
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