| The Effect of Preemptive Local Infiltration of Lidocaine and Gabapentin on Postoperative Pain in Rats. |
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Hae Kyu Kim, Hyun Sub Lee, Inn Se Kim, Seong Wan Baik, Jae Young Kwon, Sang Uk Shin |
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Department of Anesthesiology, College of Medicine, Pusan National University, Busan, Korea. |
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| Abstract |
BACKGROUND
Preemptive analgesia may improve postoperative antinociceptive treatment that prevents the development of central sensitization which contributes to post-injury pain hypersensitivity. However, beneficial effects of preemptive analgesia appear controversial. The purpose of this study was to examine the effect of pre- and post-incisional local infiltration of lidocaine and gabapentin on incisional pain in rats.
METHODS
Thirty five male rats were divided into 7 groups; control group (n = 5), pre-lidocaine infiltration group (n = 5), post-lidocaine infiltration group (n = 5), pre-gabapentin 10 mg infiltration group (n = 5), post-gabapentin 10 mg infiltration group (n = 5), pre-gabapentin 30 mg infiltration group (n = 5), and post-gabapentin 30 mg infiltration group (n = 5). To evaluate postoperative mechanical hyperalgesia in injured feet, withdrawal thresholds were measured by calibrated von Frey filaments at 2 hrs, 1, 2, 3, 4, and 5 days after an incision.
RESULTS
The pre-lidocaine infiltration group shows better analgesic effects than post-lidocaine infiltration group until postoperative day 1 (P < 0.05). The gabapentin infiltration groups were effective in postoperative pain management but there were no significant differences between pre- and post- incisional treatment.
CONCLUSIONS
A preemptive lidocaine injection has a good analgesic effect on incisional pain. Gabapentin also has a good analgesic effect on incisional pain. |
| Key Words:
Analgesia: preemptive; Anesthetics, local: lidocaine; Animals: rats; Anticonvulsants: gabapentin |
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