Korean J Anesthesiol Search

CLOSE


Korean Journal of Anesthesiology 1999;36(5):790-794.
DOI: https://doi.org/10.4097/kjae.1999.36.5.790   
Comparison of Verapamil and Esmolol for Controlling the Blood Pressure and Heart Rate to Tracheal Intubtion.
Yong Son, Dong Ryul Lee, Yoon Kang Song, Tai Yo Kim
Department of Anesthesiology, Wonkwang University School of Medicine, Iksan, Korea.
Abstract
BACKGROUND
The antihypertensive agents such as verapamil and esmolol are well known about effects of hemodynamic stabilization to tracheal intubation. The aim of the present study was to compare and evaluate the efficacy of those for controlling hemodynamic responses to tracheal intubation.
METHODS
Thirty six patients, ASA physical status I or II, were randomly assigned to one of three groups (n=12 each): saline (control), verapamil 0.1 mg/kg and esmolol 1 mg/kg. Anesthesia was induced with thiopental 5 mg/kg intravenously, and then saline, verapamil and esmolol were administered as an intravenous bolus, and immediately followed by succinylcholine 1.5 mg/kg. Tracheal intubation was done 60 s and 90 s after intravenous injection of verapamil and esmolol, respectively. Systolic and diastolic blood pressure and heart rate were measured before induction and every min for 5 minutes after tracheal intubation.
RESULTS
There was a significant attenuation in systolic and diastolic arterial pressure after tracheal intubation in verapamil group compared to control group. Heart rate was significantly lower in esmolol group than in verapamil group after tracheal intubation.
CONCLUSIONS
Verapamil 0.1 mg/kg and esmolol 1 mg/kg attenuated the increases in blood pressure and heart rate after tracheal intubation, respectively.
Key Words: Intubation, trachea, sympathetic stimulation; Pharmacology, verapamil, esmolol


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
(서울특별시 마포구 마포대로 109 롯데캐슬 프레지던트 101동 3503호)
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                
Business Name: Korean Society of Anesthesiologists (대한마취통증의학회)
Business Registration: 106-82-07194
Representative: Jun Heum Yon (연준흠)

Copyright © 2024 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next