| Coagulation Status Changes during Progressive Hemodilution. |
|
Young Soon Choi, Woo Jae Joun, Gaab Soo Kim, Tae Soo Hahm, Chung Su Kim, Baek Hyo Shin |
|
|
|
|
|
|
| Abstract |
BACKGROUND
Hemodilution reduces the concentration of clotting factors in blood and this may induce some degree of impairment of coagulation. But there are some evidence that hemodilution may induce a hypercoagulable state. The goal of this study is to investigate the changes of coagulation status during progressive hemodilution.
METHODS
Whole Blood was diluted by 10% increment to 80% with 0.9% normal saline. At each 10% dilution blood coagulation status was analysed using thrombelastography (TEG) and was compared with that of an undiluted control specimen obtained concurrently from the same patients.
RESULTS
Hemodilutions up to 40% decrease r and K times and increase values of MA and angle. Hemodilutions more than 70% increase r and K times and decrease values of MA and angle.
CONCLUSIONS
Hemodilutions up to 40% increase coagulability and hemodilutions more than 70% decrease coagulability of whole blood in vitro. |
| Key Words:
Blood, coagulation, hemodilution, thrombelastography |
|
PDF Links
Full text via DOI
Download Citation
