| Effect of Doxapram Hydrochloride on Respiration after General Anesthesia. |
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Tae Suck Shin, Kyu Suck Suh, Dong Won Lim, Sang Ho Jin |
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Department of Anesthesiology, School of Medicine, Kyung Hee University, Seoul, Korea. |
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| Abstract |
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The effect of a new analeptic, doxapram hydrochloride, on respiration has been studied in ten subjects anesthetized with thiopental or with nitrous oxide-oxygen-halothane. The results are as follows: 1) Respiratory stimulation was more pronounced in the group anesthetized with thiopental than that with nitrous oxide-oxygen-halothane. 2) The stimulatory effect lasted for four minutes. Subjects who received multiple doses of the drug, however, showed a cumulative effect. 3) Most cases showed moderate hypertensive effect and brief electrocardiographic change was observed in one of the ten. |
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