Salmon-Calcitonin; Analgesic Effect and Influence on the Morphine Induced Analgesia.

Leem,  Jeong Gill

doi:1995.28.3.370

Clinical Research Article

Korean Journal of Anesthesiology 1995;28(3):370-375.
DOI: https://doi.org/10.4097/kjae.1995.28.3.370

Salmon-Calcitonin; Analgesic Effect and Influence on the Morphine Induced Analgesia.

Jeong Gill Leem

Department of Anesthesiology, College of Medicine, University of Ulsan, Korea.

Abstract

Calcitonin is a peptide hormone involved primarily in the regulation of calcium homeostasis. However,clinical observations have shown that calcitonin does in fact possess an analgesic effect in a variety of painful disorders. So I studied the analgesic effect of intracerebroventricularly(i.c.v.) administered salmon calcitonin(s-CT) using the hot plate test and writhing test. The influence on the analgesia induced by morphine and naloxone reversibility was also studied. When s-CT was administered i.c.v., analgesia was observed in both tests,although it was greater in the writhing test than in the hot plate test. The analgesic effect of s-CT was partially but significantly reversed by naloxone. Thus, these results provide information about the antinociceptive effect of s-CT via interaction with both opiate and non-opiate mechanisms.

Key Words: salmon-Calcitonin; Morphine; Analgesia