| Factors Influencing the Clinical Duratin of Vecuronium Bromide in Patients with Chronic Renal Failure. |
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Kyo Sang Kim |
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Department of Anesthesiology, College of Medicine, Hanyang University, Seoul, Korea. |
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| Abstract |
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The clinical duration(the time from onset unitl 25% recovery of base line twitch amplitude) of vecuronium bromide(vecuronium) in patients with chronic renal failure showed great individual variations. The factors that influence the action of vecuronium were hypothermia, biliary and urinary excretion, electrolyte imbalance and acid base status, age, etc. The purpose of this study was to examine the relationship between influencing factors and clinical duration of vecuronium in patients without renal function.
Thirty patients for renal transplantation were applied ulnar nerve stimuli of every 10 seconds single twitch using Myotest MK II . The adduction force of the resultant thumb twitch was measured by the acceleration of Mini-accelograph and recorded by Datascope 2200 I . After intravenous vecuronium 0.12mg/kg, the duration of action was measured during anesthesia with 1- 1.5% isoflurane and 50% nitrous oxide. The results were as follows : 1) There were only a significant relationship between clinical duration of vecuronum and diagnostic duration(the duration from diagnosis to operation). 2) I thought the clinical duration of male was longer thsn that of female was due to longer diagnostic duration of male. 3) I could not suspect the changes of clinical duration after small increased vecuronium in patients without kidney function, due to great individual variations. With the above results the author concluded that the clinical duration of vecuronium was followed by the diagnostic duration in patients without kidney function. |
| Key Words:
Chronic renal failure; Vecuronium bromide; Clinical duration; Diagnostic dura- tion |
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