Study for Addictive Effect of Glycopyrrolate (Robinul) and Neostigmine .

Kwon,  Gab Soo; Kim,  Yong III; Ha,  In Ho; Kim,  Sang Soo

doi:1982.15.4.458

Clinical Research Article

Korean Journal of Anesthesiology 1982;15(4):458-463.
DOI: https://doi.org/10.4097/kjae.1982.15.4.458

Study for Addictive Effect of Glycopyrrolate (Robinul) and Neostigmine .

Gab Soo Kwon, Yong III Kim, In Ho Ha, Sang Soo Kim

¹Department of Anesthesiology, Chonnam National University Medical School, Kwangju, Korea.
²Department of Anesthesiology, Chosun University Grauate School, Kwangju, Korea.

Abstract

The purpose of this study was to observe the additive effect of glycopyrrolate and neostigmine on the heart rate in healthy young volunteer. The authors administered glycopyrrolate and neostigmine intravenously, and compared its effect on the heart rate in both drugs. The results were as follows: 1) A small dose of glycopyrrolate(0.1mg) showed a slight decrease in the heart rate. 2) Neostigmine(0.5mg) showed a significant decrease in the heart rate. 3)glycopyrrolate(0.1mg) 10minutes after glycopyrrolate(0.1mg), showed a marked increase in the heart rate. 4) Neostigmine(0.5mg), 10 min. after glycopyrrolate(0.1mg), showed a significant decrease in the heart rate. 5) glycopyrrolate(0.1mg), 10 min. after neostigmine(0.5mg), showed a decrease in the heart rate. 6) The above results suggest that the site of action of glycopyrrolate is at variance with that of neostigmine.